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Updated: Jul 23, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Pharmacologic Treatment Strategies in Psoriatic Arthritis
G Ayan1, A Ribeiro2, Betul Macit3
1Hacettepe University, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.
Clinical Therapeutics
|July 16, 2023
Summary
This review summarizes current psoriatic arthritis (PsA) treatments, highlighting domain-specific efficacy and the need for personalized care. Tailoring therapies based on disease phenotype and comorbidities is crucial for optimal outcomes in psoriatic arthritis management.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting joints, skin, and entheses.
- Effective management requires addressing diverse disease domains and related conditions.
Purpose of the Study:
- To present current therapeutic strategies for psoriatic arthritis (PsA).
- To support treatment decisions using a domain-based approach for PsA management.
Main Methods:
- A narrative review of treatment strategies for PsA.
- Searches included PubMed, EMBASE, international guidelines, and congress abstracts.
- Focused on disease domains: peripheral arthritis, enthesitis, axial disease, dactylitis, skin/nail disease, and related conditions (uveitis, IBD).
Main Results:
- Multiple treatments exist, including TNF inhibitors, IL-17, IL-12/23, IL-23, JAK inhibitors, apremilast, and abatacept.
- No single agent excels in peripheral arthritis/dactylitis; IL-17/IL-12/23 inhibitors may outperform TNF inhibitors for enthesitis.
- IL-17 inhibitors show superiority for skin PsA; TNF inhibitors are preferred for PsA with uveitis; IL-17 inhibitors should be avoided in PsA with IBD.
Conclusions:
- Numerous therapeutic options are available for PsA, with more emerging.
- Individualized treatment plans based on phenotype, comorbidities, and patient preference are essential.
- Shared decision-making is key for optimizing psoriatic arthritis care.
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