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Recent Developments in Coumarin Derivatives as Neuroprotective Agents.

Prakash Shyambabu Mishra1, Amit Kumar1, Kamalpreet Kaur1

  • 1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda, Bathinda (Pb.), 151401, India.

Current Medicinal Chemistry
|July 17, 2023
PubMed
Summary

Coumarin derivatives show promise as neuroprotective agents against debilitating neurodegenerative diseases. This review explores their synthesis and structure-activity relationships for developing safer, more effective treatments.

Keywords:
ChE inhibitorsMAO-B inhibitorsNeuroprotectioncoumarinsneuro.neurodegeneration

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Area of Science:

  • Medicinal Chemistry
  • Neuroscience
  • Pharmacology

Background:

  • Neurodegenerative diseases pose a significant global health burden due to complex pathophysiology.
  • Current treatments offer only symptomatic relief with potential side effects.
  • Developing novel neuroprotective agents is crucial for managing these conditions.

Purpose of the Study:

  • To review literature on coumarin derivatives as potential neuroprotective agents.
  • To explore synthetic strategies for generating coumarin-based compounds.
  • To identify structure-activity relationships for designing improved neurotherapeutics.

Main Methods:

  • Comprehensive literature search on coumarin synthesis and neuroprotection.
  • Compilation of synthetic routes for coumarin derivatives.
  • Analysis of structure-activity relationships for coumarin scaffolds.

Main Results:

  • Coumarins and their derivatives exhibit diverse mechanisms of neuroprotection.
  • The coumarin scaffold can be modified to target various pathways implicated in neurodegeneration.
  • Literature supports the potential of coumarins in developing novel neuroprotective therapies.

Conclusions:

  • Coumarin's oxaheterocyclic loop facilitates protein binding, underpinning its neuroprotective activity.
  • Coumarin serves as a promising pharmacophore for designing new drugs against neurodegenerative diseases.
  • Further research into coumarin derivatives is warranted for effective neuroprotection.