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Updated: Jul 23, 2025
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Commentary on a Classic JHC Article on Intracellular Hyaluronan Associated With the Mitotic Spindle
Stephen P Evanko1, Thomas N Wight1
1Center for Fundamental Immunology, Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA.
Abstract:
The authors of the accompanying classic paper from the Journal of Histochemistry and Cytochemistry (Evanko SP, Wight TN. Intracellular Localization of Hyaluronan in Proliferating Cells. Journal of Histochemistry & Cytochemistry. 1999;47[10]:1331-1341) comment on the impact and significance of their findings on the intracellular localization of hyaluronan in arterial smooth muscle cells using immunohistochemical techniques. These seminal findings signaled the potential for a role of hyaluronan in the functions of microtubules and mitosis.
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