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Wells Syndrome with Generalized Oedema
Magdalini Manti1, Efthymia Pappa1, Vasiliki Arkouli1
1First Internal Medicine Department, "Sismanoglio" General Hospital, Athens, Greece.
European Journal of Case Reports in Internal Medicine
|July 17, 2023
Summary
Wells syndrome, a rare skin condition, and Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis) may share overlapping features. This suggests they might be part of the same disease entity, requiring biopsies for diagnosis.
Area of Science:
- Dermatology
- Immunology
- Rheumatology
Background:
- Wells syndrome (eosinophilic cellulitis) is a rare, relapsing skin disease without systemic involvement.
- Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis, EGPA) is an autoimmune disease with multiorgan and cutaneous manifestations.
Purpose of the Study:
- To report a case with overlapping features of Wells syndrome and Churg-Strauss syndrome.
- To suggest a potential shared nosological entity between these two conditions.
Main Methods:
- Clinical case presentation.
- Histopathological examination of skin biopsy specimens.
Main Results:
- The case exhibited features characteristic of both Wells syndrome and Churg-Strauss syndrome.
- Skin biopsies were crucial for diagnosing this unusual presentation of cellulitis.
Conclusions:
- Biopsies are essential for diagnosing atypical cellulitis cases.
- COVID-19 vaccination is a potential trigger for Wells syndrome.
- Significant overlap exists between Wells syndrome and Churg-Strauss syndrome, indicating a possible link.
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