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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Disorder of Water Balance01:29

Disorder of Water Balance

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Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

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The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
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Related Experiment Video

Updated: Jul 23, 2025

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
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Wells Syndrome with Generalized Oedema.

Magdalini Manti1, Efthymia Pappa1, Vasiliki Arkouli1

  • 1First Internal Medicine Department, "Sismanoglio" General Hospital, Athens, Greece.

European Journal of Case Reports in Internal Medicine
|July 17, 2023
PubMed
Summary

Wells syndrome, a rare skin condition, and Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis) may share overlapping features. This suggests they might be part of the same disease entity, requiring biopsies for diagnosis.

Keywords:
Churg-Strauss syndromeWells syndromecellulitiseosinophiliavasculitis

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Area of Science:

  • Dermatology
  • Immunology
  • Rheumatology

Background:

  • Wells syndrome (eosinophilic cellulitis) is a rare, relapsing skin disease without systemic involvement.
  • Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis, EGPA) is an autoimmune disease with multiorgan and cutaneous manifestations.

Purpose of the Study:

  • To report a case with overlapping features of Wells syndrome and Churg-Strauss syndrome.
  • To suggest a potential shared nosological entity between these two conditions.

Main Methods:

  • Clinical case presentation.
  • Histopathological examination of skin biopsy specimens.

Main Results:

  • The case exhibited features characteristic of both Wells syndrome and Churg-Strauss syndrome.
  • Skin biopsies were crucial for diagnosing this unusual presentation of cellulitis.

Conclusions:

  • Biopsies are essential for diagnosing atypical cellulitis cases.
  • COVID-19 vaccination is a potential trigger for Wells syndrome.
  • Significant overlap exists between Wells syndrome and Churg-Strauss syndrome, indicating a possible link.