Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Impact of smoking on subtypes and molecular profile of breast cancer: a systematic review.

Exploration of targeted anti-tumor therapy·2026

Same journal

Why precision oncology works: lessons from gastrointestinal stromal tumours.

Exploration of targeted anti-tumor therapy·2026

Same journal

More than alternative estrogen receptors: the emerging role of GPER-1 and ERα36 in breast cancer.

Exploration of targeted anti-tumor therapy·2026

Same journal

Oncologic outcome and safety profile of first-line enfortumab vedotin plus pembrolizumab vs. conventional chemotherapy in advanced urothelial cancer.

Exploration of targeted anti-tumor therapy·2026

Same journal

RNA therapeutic targeting of recalcitrant and rare cancers.

Exploration of targeted anti-tumor therapy·2026

Same journal

<i>ESR1</i> mutations in ER-positive breast cancer: from endocrine resistance to ctDNA-guided therapeutic interception.

Exploration of targeted anti-tumor therapy·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 23, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Capitalizing glycomic changes for improved biomarker-based cancer diagnostics.

Maria Luísa S Silva¹

¹Unidade de Aprendizagem ao Longo da Vida, Universidade Aberta, 1269-001 Lisboa, Portugal.

Exploration of Targeted Anti-Tumor Therapy

|July 17, 2023

Summary

This summary is machine-generated.

Analyzing cancer serum biomarkers alongside their glycoforms significantly improves cancer detection. This combined approach enhances sensitivity and specificity for more powerful diagnostic tests.

Keywords:

Cancer aberrant glycosylation assays biomarkers sensitivity specificity

More Related Videos

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Related Experiment Videos

Last Updated: Jul 23, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Area of Science:

Biochemistry
Oncology
Biomarker Discovery

Background:

Cancer serum biomarkers are crucial for diagnostics and monitoring.
Most biomarkers are glycoproteins with cancer-specific glycan structures.
Current assays often neglect glycan analysis, limiting information.

Purpose of the Study:

To demonstrate the advantages of combined protein and glycoform analysis for cancer biomarkers.
To highlight how this strategy enhances diagnostic power.
To overcome limitations of analyzing protein amount or glycoform alone.

Main Methods:

Narrative review of existing research and clinical examples.
Focus on specific biomarkers like alpha-fetoprotein (AFP) and cancer antigen 19-9 (CA19-9).
Analysis of combined quantification strategies.

Main Results:

Combined quantification yields maximum information from biomarkers.
This strategy overcomes weaknesses of individual analyses.
Examples show improved sensitivity and specificity in cancer detection.

Conclusions:

Combined protein and glycoform analysis of cancer biomarkers offers superior diagnostic utility.
This integrated approach enhances cancer monitoring and detection capabilities.
Exploiting differential glycan structures is key to maximizing biomarker potential.