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Role of circulating CD14++CD16+ monocytes and VEGF-B186 in formation of collateral circulation in patients with
He Zhang1, Shi-Lei Wang2, Tao Sun3
1Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, 050000, China.
Insights
Higher levels of intermediate monocytes and VEGF-B186 in acute myocardial infarction (AMI) patients correlate with better collateral circulation. This suggests these factors are key for healing AMI and improving blood flow.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Regenerative Medicine
Background:
- Insufficient collateral circulation is a significant issue in acute myocardial infarction (AMI) patients.
- CD14++CD16+ monocytes (intermediate monocytes, IM) and vascular endothelial growth factors (VEGFs) are linked to collateral circulation development.
Purpose of the Study:
- To investigate the association between circulating intermediate monocytes, VEGF levels, and collateral formation in AMI patients.
- To explore the relationship between these factors and left ventricular remodeling post-AMI.
Main Methods:
- Enrolled 49 patients with AMI undergoing emergency percutaneous transluminal coronary intervention (PCI) and 27 patients undergoing delayed PCI.
- Measured circulating IM percentage and VEGF levels on day 8 post-AMI; assessed left ventricular ejection fraction (LVEF) at 3 months.
Main Results:
- Patients with well-developed collateral circulation had higher IM and VEGF levels on day 8.
- VEGF-B186 levels positively correlated with IM in circulation.
- Higher IM and VEGF-B186 levels were associated with milder left ventricular remodeling.
Conclusions:
- Hyperacute collateral formation in AMI is linked to increased circulating CD14++CD16+ monocytes and VEGF-B186.
- Targeting IM and VEGF-B may be crucial for enhancing collateral circulation and promoting healing in AMI.
Introduction:
Collateral formation is insufficient in some patients with acute myocardial infarction (AMI). Peripheral blood CD14++CD16+ monocytes (intermediate monocytes; IM) and vascular endothelial growth factors (VEGFs) are associated with formation of collateral circulation.
Methods:
We enrolled 49 patients with AMI who underwent emergency percutaneous transluminal coronary intervention (PCI) (Group A) and 27 patients underwent delayed PCI 1 week after AMI (Group B). The percentage of circulating IM and levels of VEGFs in circulation were determined on day 8th. Left ventricular ejection fraction (LVEF) was measured 3 months after AMI.
Results:
The peripheral levels of IM and serum VEGF levels on day 8th were significantly higher in patients with well-developed collateral circulation in Group A than those in Group B. The levels of circulating VEGFs in the collateral circulation (+) subgroup in Group B were lower than those in the collateral circulation (-) subgroup. Moreover, the serum VEGF-B186 levels positively correlated with IM.
Conclusions:
Hyperacute collateral formation in patients with AMI correlated with a higher percentage of CD14++CD16+ monocytes and VEGF-B186 levels in the circulation, which was associated with milder left ventricular remodeling. The regulation of CD14++CD16+ monocytes and VEGF-B may be critical to the formation of collateral circulation and to healing AMI.
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