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Updated: Jul 23, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Placental abruption leading to disseminated intravascular coagulation: a clinical case and short review

Meghan G Hill1, Aimee Brighton2, Wendy Burgess1

  • 1Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand (Drs Hill and Burgess).

AJOG Global Reports
|July 17, 2023
PubMed

We present the case of a primigravida with disseminated intravascular coagulation at 21 weeks' gestation. Furthermore, we performed a short review of the evidence-based management of the condition. The patient presented with pain and vaginal bleeding. Clinical examination, laboratory studies, and an abdominal ultrasound produced inconclusive results about the origin of her disseminated intravascular coagulation. She was transferred to a tertiary facility where blood and plasma product transfusions were performed, and further investigations revealed fetal demise caused by placental abruption as the underlying cause of her disseminated intravascular coagulation. Cervical preparation was conducted with a balloon catheter and misoprostol. Surgical evacuation of her uterus was performed and she made a full recovery.

Keywords:
blood component transfusioncervical ripeningdisseminated intravascular coagulationmisoprostolplacental abruption

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