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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
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mRNA Delivery Platform Based on Bacterial Outer Membrane Vesicles for Tumor Vaccine

Xiaoyu Gao1,2, Yao Li1,3, Guangjun Nie1,2

  • 1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

Bio-Protocol
|July 17, 2023
PubMed
Summary

Bacteria-derived outer membrane vesicles (OMVs) engineered with L7Ae protein offer a novel platform for rapid delivery of customized tumor mRNA vaccines. This Plug-and-Display strategy bypasses limitations of current methods for personalized cancer immunotherapy.

Keywords:
BoxC/DCancer immunotherapyOuter membrane vesiclesRNA binding proteinRapid displaymRNA vaccines

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