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Olmesartan-Induced Enteropathy: A Case Report

Dharmikkumar Jadvani1, Pinky Jha2, Meenu Singh3

  • 1Internal Medicine, Byramjee Jeejeebhoy (BJ) Medical College, Ahmedabad, IND.

Cureus
|July 17, 2023
PubMed

Insights

Olmesartan-induced enteropathy causes unexplained diarrhea and weight loss. Discontinuing olmesartan medication rapidly resolved symptoms in a patient, highlighting its importance in diagnosis.

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Olmesartan-induced enteropathy is a rare adverse drug reaction.
  • It presents with chronic diarrhea and weight loss, mimicking other small intestine diseases.
  • Timely diagnosis is often challenging due to overlapping clinical and histological features.

Observation:

  • A 58-year-old male on long-term olmesartan developed severe diarrhea, weight loss (35 lbs), acute kidney injury, and hypokalemia.
  • Extensive investigations including upper and lower endoscopy with biopsies, autoimmune markers, and infectious disease workup were negative.
  • Symptoms emerged during travel, suggesting a potential environmental or drug-related trigger.

Findings:

  • Olmesartan-induced enteropathy was diagnosed as a diagnosis of exclusion.
  • Discontinuation of olmesartan led to rapid improvement and resolution of diarrhea within days.
  • This case underscores the gastrointestinal side effects of olmesartan.

Implications:

  • Early recognition and drug withdrawal are crucial for managing olmesartan-induced enteropathy.
  • Physicians should consider this diagnosis in patients with unexplained chronic diarrhea on olmesartan.
  • Further research into the pathogenesis and diagnostic markers is warranted.
Keywords:
adverse drug effectceliac spruediarrhea and abdominal painolmesartan-induced enteropathyvillous atrophy

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