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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
293
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
357
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
195
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

337
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Related Experiment Video

Updated: Jul 23, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Viral Triggered Celiac Disease: A Case Report.

Nicole L Welch1, Tyler Welch2, Busara Songtanin1

  • 1Internal Medicine, Texas Tech University Health Sciences Center Lubbock Campus, Lubbock, USA.

Cureus
|July 17, 2023
PubMed
Summary

Celiac disease (CD) is an autoimmune disorder triggered by gluten. This case highlights how viral infections like mononucleosis may precipitate CD symptoms in predisposed individuals.

Keywords:
autoimmuneceliac diseasecytomegalovirus (cmv)ebvepstein barr virusmononucleosisoral tolerance

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Area of Science:

  • Gastroenterology
  • Immunology
  • Virology

Background:

  • Celiac disease (CD) is an autoimmune disorder with diverse, nonspecific gastrointestinal symptoms, complicating diagnosis.
  • CD involves gluten sensitivity and can lead to malabsorption, deficiencies, and failure to thrive.
  • Diagnosis typically requires screening blood tests and confirmatory small intestine biopsy.

Observation:

  • Viral infections are known triggers for autoimmune conditions.
  • Epstein-Barr virus (EBV) and Cytomegalovirus (CMV) are potential triggers for celiac disease in genetically susceptible individuals.
  • This case report details a patient who developed celiac disease symptoms shortly after a mononucleosis diagnosis.

Findings:

  • The patient presented with symptoms consistent with celiac disease following a diagnosis of mononucleosis.
  • This suggests a potential link between viral infections and the clinical manifestation of celiac disease.
  • Early identification of celiac disease is crucial for managing complications.

Implications:

  • Viral infections may act as a precipitating factor for celiac disease in susceptible individuals.
  • Understanding these triggers can improve early diagnosis and management strategies for celiac disease.
  • Further research into the viral triggers of autoimmune diseases like celiac disease is warranted.