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Related Experiment Video

Updated: Jul 23, 2025

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
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Cell cycle dynamics control fluidity of the developing mouse neuroepithelium.

Laura Bocanegra-Moreno1, Amrita Singh1, Edouard Hannezo1

  • 1Institute of Science and Technology Austria, Klosterneuburg, Austria.

Nature Physics
|July 17, 2023
PubMed
Summary

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Developing mouse spinal cord epithelium remains fluid through nuclear movements driving cell rearrangements. Tissue solidification occurs as proliferation slows, similar to a glass transition, not jamming.

Area of Science:

  • Developmental biology
  • Biophysics
  • Tissue engineering

Background:

  • Growing tissues change material properties due to cell dynamics like tension and jamming.
  • Cellular mechanisms governing the physical state of developing tissues are often unclear.

Purpose of the Study:

  • To investigate the cellular mechanisms controlling the physical state of developing epithelia.
  • To understand how tissue fluidity and solidification occur during early development.

Main Methods:

  • Analysis of tissue mechanics in developing mouse spinal cord epithelium.
  • Investigating the role of interkinetic nuclear movements in cell area dynamics and rearrangements.
  • Correlating proliferation rates with tissue solidification over developmental time.
Keywords:
Biological physicsBiophysics

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Related Experiment Videos

Last Updated: Jul 23, 2025

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
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Published on: June 4, 2014

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High-resolution Live Imaging of Cell Behavior in the Developing Neuroepithelium
10:59

High-resolution Live Imaging of Cell Behavior in the Developing Neuroepithelium

Published on: April 12, 2012

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Ex vivo Live Imaging of Single Cell Divisions in Mouse Neuroepithelium
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Main Results:

  • Early developmental epithelia exhibit high junctional tension and fluidity.
  • Interkinetic nuclear movements generate cell area dynamics, facilitating extensive cell rearrangements.
  • Tissue solidification is observed as the cell proliferation rate declines over time.

Conclusions:

  • Tissue solidification in developing epithelia resembles a glass transition, driven by dynamical stresses from growth and differentiation.
  • Interkinetic nuclear movements and growth dynamics are key factors in regulating epithelial fluidity.
  • Findings are relevant to understanding multiple developing tissues and potential applications in tissue engineering.