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Nuclear Factor-κB is a Prime Candidate for the Diagnosis and Control of Inflammatory Cardiovascular Disease

Akira Matsumori1

  • 1Clinical Research Institute, National Hospital Organization, Kyoto Medical Center Kyoto, Japan.

European Cardiology
|July 17, 2023
PubMed

Insights

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling regulates inflammation and immunity. Inhibiting NF-κB shows therapeutic potential for cardiovascular diseases, diabetes, and inflammatory conditions.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pharmacology

Background:

  • Nuclear factor kappa-light-chain-enhenser of activated B cells (NF-κB) is a key regulator of inflammatory and immune responses.
  • NF-κB activation is implicated in the pathogenesis of cardiovascular diseases (CVDs), atherosclerosis, and diabetes.

Purpose of the Study:

  • To review recent advances in understanding the NF-κB signaling pathway's role in inflammation, metabolism, and immunity.
  • To explore the diagnostic and therapeutic potential of targeting NF-κB for various human diseases.

Main Methods:

  • Literature review of studies on NF-κB signaling.
  • Analysis of therapeutic agents and natural compounds that inhibit NF-κB.
  • Discussion of immunoglobulin-free light chains as potential biomarkers.

Main Results:

  • Therapeutic agents like pimobendan and SGLT2 inhibitors demonstrate anti-inflammatory effects via NF-κB inhibition.
  • Pharmacological agents and natural compounds can inhibit NF-κB, offering treatment options for inflammatory diseases.
  • Immunoglobulin-free light chains may serve as biomarkers for NF-κB activation and treatment efficacy.

Conclusions:

  • Targeting the NF-κB pathway holds significant promise for developing novel diagnostics and therapeutics for inflammatory diseases, CVDs, and diabetes.
  • Further research into NF-κB signaling can lead to improved management strategies for these conditions.

Keywords:
Atherosclerosisbiomarkerdiabetesheart failureimmunoglobulin light chainsnuclear factor-κBsodium–glucose cotransporter 2 inhibitor

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