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Related Concept Videos

CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Homologous Recombination02:31

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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CRISPR and crRNAs02:53

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Updated: Jul 23, 2025

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
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Erratum: Inflammation conditional genome editing mediated by the CRISPR-Cas9 system.

Tingting Yuan, Honglin Tang, Xiaojie Xu

    Iscience
    |July 17, 2023
    PubMed
    Summary

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for scientific research, maintaining data integrity.

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    Area of Science:

    • Bibliometrics
    • Scientific Publishing
    • Scholarly Communication

    Context:

    • Accurate citation is crucial for scientific integrity.
    • Maintaining correct article identifiers ensures proper referencing.
    • The scientific community relies on precise metadata for research tracking.

    Purpose:

    • To correct an error in a previously assigned Digital Object Identifier (DOI).
    • To ensure the scientific record is accurate and retrievable.
    • To provide the correct DOI for the article published in iScience.

    Summary:

    • This entry serves as a correction notice for an article.
    • The Digital Object Identifier (DOI) has been updated to 10.1016/j.isci.2023.106872.
    • This ensures the article is correctly identified and linked within scholarly databases.

    Impact:

    • Enhances the reliability of scientific literature.
    • Facilitates accurate citation and retrieval of research.
    • Supports the integrity of scholarly communication and bibliometric analysis.