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Caenorhabditis elegans in microgravity: An omics perspective
Amanda Scott1, Craig R G Willis2, Masafumi Muratani3
1Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Iscience
|July 17, 2023
Summary
Spaceflight significantly impacts organism physiology, as revealed by omics studies in Caenorhabditis elegans (C. elegans). This research highlights conserved metabolic and neuromuscular changes, supporting C. elegans as a model for spaceflight research.
Area of Science:
- Space biology
- Molecular biology
- Genomics
Background:
- Omics research in Caenorhabditis elegans (C. elegans) is increasingly used to understand spaceflight's biological effects.
- Spaceflight induces wide-ranging physiological impacts on organisms.
Purpose of the Study:
- To review the application of various omics approaches (genomics, transcriptomics, proteomics, multi-omics) in studying spaceflown C. elegans.
- To discuss the impact, utility, and future directions of C. elegans space omics research.
Main Methods:
- Review of existing literature on omics studies of spaceflown C. elegans.
- Analysis of molecular alterations, particularly gene regulation in metabolism and neuromuscular systems.
Main Results:
- Spaceflight causes significant molecular alterations in C. elegans, notably affecting metabolic and neuromuscular gene regulation.
- These transcriptional changes are reproducible across different species, including mice and astronauts.
- C. elegans serves as a valuable model organism for spaceflight research due to its translational relevance.
Conclusions:
- Omics research in C. elegans provides crucial insights into spaceflight's physiological impacts.
- Future research integrating tissue-specific, spatial, and multi-omics approaches will identify therapeutic targets for spaceflight-induced changes.
