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Updated: Jul 23, 2025
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Binocular head-mounted chromatic pupillometry can detect structural and functional loss in glaucoma
Yadan Quan1,2,3, Huiyu Duan4, Zongyi Zhan5
1Department of Ophthalmology and Visual Science, Shanghai Medical College, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
Frontiers in Neuroscience
|July 17, 2023
Summary
Binocular chromatic pupillometry effectively detects impaired pupillary light response in primary open-angle glaucoma (POAG) patients. This method shows promise for opportunistic POAG diagnosis in community and telemedicine settings.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Technology
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Early detection of POAG is crucial for preventing vision loss.
- Current diagnostic methods may not be suitable for widespread opportunistic screening.
Purpose of the Study:
- To evaluate binocular chromatic pupillometry for detecting impaired pupillary light response (PLR) in POAG patients.
- To assess the feasibility of using this technology for opportunistic POAG diagnosis in community or telemedicine settings.
Main Methods:
- Prospective, cross-sectional study involving 74 POAG patients and 23 healthy controls.
- Comprehensive ophthalmologic exams, including OCT and SAP.
- Pupillary light response (PLR) tests using chromatic stimuli targeting rods, ipRGCs, and cones, and a relative afferent pupillary defect (RAPD) test with chromatic flashes.
Main Results:
- POAG patients exhibited significantly reduced PLR across all tested conditions.
- Time to maximum dilation (ipRGC-weighted) and constriction amplitude (cone- and ipRGC-weighted) were key indicators.
- Infrared pupillary asymmetry (IPA) and anisocoria duration were significantly greater in POAG patients and correlated with visual field loss.
Conclusions:
- Binocular chromatic pupillometry serves as an objective clinical tool for opportunistic glaucoma diagnosis.
- This technology enables accurate, objective, and rapid assessment of retinal structural and functional loss in glaucoma.
