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Published on: April 11, 2019
Jarisch‒Herxheimer reaction
Manjyot Gautam1, Sahil Sethi1, Nitin J Nadkarni1
1Department of Dermatology, Venerology and Leprosy, Dr. D.Y. Patil Medical College and Hospital, Navi Mumbai, Maharashtra, India.
Abstract:
Syphilis is caused by a spirochete, Treponema pallidum. Diagnosis of syphilis is made with a venereal disease research laboratory test. Treatment of choice is intramuscular injection benzathine Penicillin. The Jarisch‒Herxheimer reaction (JHR) is a transient immunological phenomenon that can occur in patients during treatment for syphilis with penicillin. It is a rare phenomenon but can be a potentially severe one. It manifests clinically with short-term constitutional symptoms such as fever, chills, headache, and myalgia, besides exacerbation of existing cutaneous lesions. We report the case of a 24-year-old man presenting with JHR posttreatment with benzathine penicillin.
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