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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
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Gut microbiota and irritable bowel syndrome
1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of Digestive Diseases
|July 17, 2023
Summary
Gut microbiota alterations are critical in irritable bowel syndrome (IBS) development. Modulating the gut microbiome shows therapeutic potential for IBS, but requires further clinical verification.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with unknown etiology.
- Growing evidence links gut dysbiosis to IBS development and severity.
- Previous studies show altered gut microbiota in IBS patients, but its role as a diagnostic hallmark is inconclusive.
Purpose of the Study:
- To review changes in and roles of intestinal microbiota in IBS.
- To discuss gut microbiota manipulation strategies for IBS treatment.
Main Methods:
- Literature review of studies on gut microbiota and IBS.
- Analysis of the impact of gut microbiota on IBS pathogenesis.
- Discussion of microbiota-directed therapies.
Main Results:
- Gut microbiota influences IBS via immune regulation, brain-gut-microbiome axis, and intestinal barrier function.
- High-throughput multi-omics offer insights into IBS pathogenesis and personalized treatment.
- Microbiota-directed therapies show promise but need further validation.
Conclusions:
- Gut microbiota alterations are integral to IBS pathophysiology.
- Microbiota modulation presents significant therapeutic potential for IBS.
- Large-scale, long-term clinical trials are essential to confirm treatment efficacy.
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