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Recent updates in the indolent lymphomas: Update on marginal zone lymphoma and Waldenström's macroglobulinemia

Karima Amaador1, Catherine Thieblemont2, Judith Trotman3

  • 1Department of Internal Medicine, UMC Utrecht, Utrecht, The Netherlands.

Hematological Oncology
|July 17, 2023
PubMed

Marginal Zone Lymphoma (MZL) and Waldenström's Macroglobulinemia (WM) are indolent lymphomas that both arise from post germinal center lymphocytes. Both can secrete a monoclonal protein but high levels are mostly only seen in WM. The MYD88 L256P somatic mutation that is present in an estimated 95% of patients with WM has helped greatly in differentiating the two lymphomas. Several large clinical studies with new drugs have been performed that have provided new treatment options for both MZL and WM patients. In this short review we will discuss the recent literature published and provide some recommendations.

Keywords:
Waldenstrom macroglobulinemiamarginal zone lymphomatreatment

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