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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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p38γ and p38δ modulate innate immune response by regulating MEF2D activation.

Alejandra Escós1, Ester Diaz-Mora1, Michael Pattison2

  • 1Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.

Elife
|July 17, 2023
PubMed
Summary

p38γ/p38δ kinases regulate innate immunity. New kinase-inactive p38γ/p38δ mice reveal their role in inflammatory responses and MEF2D phosphorylation, crucial for immune gene expression.

Keywords:
MAPKMEF2Dbiochemistrychemical biologyimmunologyinflammationmousep38γp38δphosphorylation

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