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Related Concept Videos

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Updated: Jul 23, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Epilepsy surgery in early infancy: A retrospective, multicenter study.

Konstantin L Makridis1,2,3,4, Kerstin Alexandra Klotz5, Georgia Ramantani6,7,8

  • 1Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Epilepsia Open
|July 17, 2023
PubMed
Summary

Early epilepsy surgery in infants can achieve good seizure control and improve development, but carries risks. Surgery should only be performed in specialized centers due to potential complications.

Keywords:
anti-seizure medicationcognitionepilepsyepilepsy surgeryinfantsneurosurgeryoutcomepediatrics

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Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Epilepsy surgery offers a cure for lesional drug-resistant epilepsy (DRE).
  • Infants are often hesitant to undergo surgery due to complication fears.
  • Limited data exists on surgical complications and cognitive outcomes in infants.

Purpose of the Study:

  • To evaluate the safety and efficacy of early epilepsy surgery in infants.
  • To assess seizure control and neurodevelopmental outcomes post-surgery.
  • To identify risks associated with epilepsy surgery in the first six months of life.

Main Methods:

  • Retrospective multicenter study of 15 infants undergoing epilepsy surgery within the first six months of life.
  • Median age at surgery was 134 days; most common cause was cortical malformation.
  • 13 patients underwent hemispherotomy; two-thirds required blood transfusions.

Main Results:

  • 57% seizure freedom at a median 1.5-year follow-up; 79% after reoperation.
  • Two severe intraoperative complications, including one death.
  • Two-thirds of patients had reduced anti-seizure medications; all showed developmental improvement.

Conclusions:

  • Early epilepsy surgery in infants can lead to significant seizure reduction and developmental gains.
  • Perioperative risks necessitate careful consideration and management.
  • Surgery should be exclusively conducted in specialized pediatric epilepsy centers.