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Implication of KDM6A in bladder cancer
Marianne Matar1, Gilles Prince1, Ibrahim Hamati1
1Hematology-Oncology Department, Hotel Dieu De France Hospital, Saint Joseph University of Beirut, Riad El Solh, Lebanon.
Pharmacogenomics
|July 17, 2023
Summary
The histone demethylase gene KDM6A is frequently mutated in bladder cancer. This review explores KDM6A
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Bladder cancer is a prevalent urogenital malignancy with frequent genetic alterations.
- The histone demethylase gene KDM6A is commonly mutated in bladder cancer, implicating its role in pathogenesis.
Purpose of the Study:
- To review the characteristics of the KDM6A gene and the consequences of its mutations in bladder cancer.
- To introduce potential KDM6A-targeted therapeutic strategies for bladder cancer treatment.
Main Methods:
- A comprehensive literature search was performed in MEDLINE and Cochrane Library databases.
- Keywords used included 'KDM6A', 'bladder cancer', 'UTX', 'treatment', and 'mutation' for articles published between July 2013 and July 2022.
- Data from 30 selected articles were independently screened, abstracted, and analyzed descriptively.
Main Results:
- Thirty articles were included, with experimental and clinical data collected and thematically grouped.
- Therapeutic strategies targeting KDM6A were identified and organized into tables for clarity.
Conclusions:
- The KDM6A gene plays a critical role in the pathogenesis of bladder cancer.
- Understanding KDM6A mutations and characteristics is crucial for developing effective bladder cancer treatments.
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