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Updated: Jul 23, 2025
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Cellular senescence in glioma.
Rafał Chojak1,2, Jawad Fares1,2, Edgar Petrosyan1,2
1Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 N. St Clair Street, Suite 2210, Chicago, IL, 60611, USA.
Journal of Neuro-Oncology
|July 17, 2023
Summary
Glioma treatments can induce cellular senescence, a tumor suppression mechanism. However, gliomas can escape senescence, promoting tumor growth and recurrence through the senescence-associated secretory phenotype (SASP).
Area of Science:
- Neuro-oncology
- Cellular biology
- Cancer research
Background:
- Glioma is the most common primary brain tumor, often resistant to treatment.
- Standard therapies like radiotherapy and temozolomide chemotherapy induce cellular senescence, a tumor suppression mechanism.
- Despite inducing senescence, gliomas frequently exhibit treatment resistance and poor prognoses.
Purpose of the Study:
- To provide an overview of cellular senescence in gliomas.
- To explore mechanisms of senescence induction, bypass, and escape in glioma.
- To examine the role of senescent cells in the tumor microenvironment and their impact on glioma progression and recurrence.
- To highlight therapeutic strategies targeting senescence in glioma treatment.
Main Methods:
- Review of existing literature on glioma, cellular senescence, and the tumor microenvironment.
- Analysis of mechanisms by which gliomas induce, bypass, or escape senescence.
- Examination of the pro-tumorigenic effects of the senescence-associated secretory phenotype (SASP).
Main Results:
- Gliomas utilize diverse strategies to circumvent senescence, maintaining a proliferative state.
- Senescent cells, while a tumor suppression mechanism, can paradoxically promote tumor growth via SASP.
- Senescent cells may contribute to glioma dormancy, recurrence, and progression.
Conclusions:
- Understanding senescence pathways is crucial for glioma treatment.
- Targeting senescent cells and their SASP presents potential therapeutic avenues for glioma.
- Further research into senescence modulation could improve outcomes for glioma patients.
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