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Maternal saliva visfatin level in term and preterm labor: A case control study
Khadijeh Nasri1, Mona Mehrabi2, Mojtaba Bayani3
1Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran.
Plos One
|July 17, 2023
Summary
Maternal saliva visfatin levels were lower in women experiencing preterm birth compared to those with term delivery. This finding suggests visfatin
Area of Science:
- Reproductive biology
- Biomarkers
- Obstetrics
Background:
- Visfatin, an inflammatory biomarker, influences immune regulation.
- Maternal visfatin levels may indicate pregnancy outcomes.
- Preterm delivery is a significant obstetric complication.
Purpose of the Study:
- To compare maternal saliva visfatin levels in women with preterm versus term delivery.
- To investigate the potential role of visfatin as a biomarker for preterm birth.
Main Methods:
- Case-control study involving 80 pregnant women (40 preterm, 40 term).
- Maternal saliva samples collected and visfatin levels measured using ELISA.
- Adjusted logistic regression analysis performed for confounding factors.
Main Results:
- Mean maternal saliva visfatin levels were significantly lower in the preterm group (4.75±2.2) compared to the term group (6.7±3.1) (p=0.001).
- This difference remained significant after adjusting for gestational diabetes, preeclampsia, BMI, and weight gain (p=0.026).
- No significant difference in visfatin levels was observed between small for gestational age (SGA) and appropriate for gestational age (AGA) groups.
Conclusions:
- Maternal saliva visfatin levels are lower in preterm deliveries.
- Visfatin may play a role in labor initiation and could be an early diagnostic marker for preterm birth.
- Further research is needed to elucidate visfatin's role in pregnancy and labor.
