Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

1.3K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.3K
Mitochondria01:37

Mitochondria

13.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.9K
Mitochondrial Membranes01:45

Mitochondrial Membranes

11.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.6K
Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

3.1K
Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
3.1K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

3.4K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.4K
Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

87.5K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
87.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Roles of megakaryocytes and platelets in myeloproliferative neoplasms.

Current opinion in hematology·2026
Same author

Protease-activated receptor 1 as an endogenous model of peptidergic Gαq-Gα12-biased G protein signaling.

Frontiers in molecular biosciences·2026
Same author

Proteomic profiling identifies systemic drivers of blood-brain barrier injury in sickle cell disease.

Blood·2026
Same author

Enhancing validation of case-control omics signatures through "minimalist" single-subject analysis (N-of-1 trials): proof of concept in sepsis.

Journal of the American Medical Informatics Association : JAMIA·2026
Same author

Protease-Activated Receptor 1 as an Endogenous Model of Peptidergic Gαq-Gα12-Biased G Protein Signaling.

bioRxiv : the preprint server for biology·2026
Same author

Platelet mTOR Is a Regulator of Sterile Immunothrombosis.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same journal

Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning.

Current opinion in hematology·2026
Same journal

Nutrition as a regulator of hematopoietic stem cell biology and transplantation.

Current opinion in hematology·2026
Same journal

From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.

Current opinion in hematology·2026
Same journal

Bidirectional relationship between metabolic and thrombotic disease mechanisms.

Current opinion in hematology·2026
Same journal

The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk.

Current opinion in hematology·2026
See all related articles

Related Experiment Video

Updated: Jul 23, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

505

Platelet mitochondria: the mighty few.

Abigail Ajanel1,2, Robert A Campbell1,2,3, Frederik Denorme1,4

  • 1University of Utah Molecular Medicine Program.

Current Opinion in Hematology
|July 17, 2023
PubMed
Summary
This summary is machine-generated.

Platelet mitochondrial dysfunction contributes to oxidative stress and thrombosis in metabolic disorders. Targeting these platelet mitochondria may offer new antithrombotic therapies with preserved hemostasis.

More Related Videos

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.3K
Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration
10:35

Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration

Published on: September 6, 2014

38.3K

Related Experiment Videos

Last Updated: Jul 23, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

505
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.3K
Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration
10:35

Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration

Published on: September 6, 2014

38.3K

Area of Science:

  • Mitochondrial biology
  • Hematology
  • Metabolic disorders

Background:

  • Platelet mitochondrial dysfunction is linked to oxidative stress, a key factor in metabolic disorders like diabetes and dyslipidemia.
  • These metabolic conditions increase the risk of thrombotic complications.

Approach:

  • Reviewing evidence on the role of platelet mitochondria in regulating reactive oxygen species and platelet procoagulant activity.
  • Examining preclinical studies that target platelet mitochondrial pathways for antithrombotic effects.

Key Points:

  • Mitochondria in platelets play crucial roles beyond energy production, including regulating oxidative stress and promoting procoagulant activity.
  • Dysfunctional platelet mitochondria contribute to and are exacerbated by oxidative stress.
  • Targeting platelet mitochondrial pathways has shown potential for antithrombotic benefits in animal models.

Conclusions:

  • Therapeutic strategies focused on platelet mitochondria could reduce thrombotic risks in patients with metabolic disorders.
  • Further clinical validation is needed to translate these promising preclinical findings into effective treatments.