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Related Experiment Videos

Increased intestinal permeability in atopic eczema.

M G Pike, R J Heddle, P Boulton

    The Journal of Investigative Dermatology
    |February 1, 1986
    PubMed
    Summary

    Children with atopic eczema show increased gastrointestinal permeability. This finding suggests potential gut abnormalities or food antigen-induced intestinal damage in pediatric eczema.

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    Area of Science:

    • Pediatric Gastroenterology
    • Dermatology
    • Immunology

    Background:

    • Atopic eczema is a common inflammatory skin condition in children.
    • Gastrointestinal (GI) permeability is a measure of the gut lining's integrity.
    • Altered GI permeability has been implicated in various immune-mediated diseases.

    Purpose of the Study:

    • To investigate gastrointestinal permeability in children diagnosed with atopic eczema.
    • To compare GI permeability between children with atopic eczema and a control group.
    • To explore potential links between gut permeability and the pathogenesis of atopic eczema.

    Main Methods:

    • Oral administration of inert disaccharide lactulose and monosaccharide rhamnose.
    • Measurement of relative urinary excretion rates of lactulose and rhamnose.

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  • Calculation of the lactulose/rhamnose ratio as an indicator of GI permeability.

    • Main Results:

    • The median lactulose/rhamnose ratio was significantly higher in children with atopic eczema (n=26) compared to controls (n=29).
    • The control group included healthy children and those with non-eczematous dermatoses.
    • A higher ratio indicates increased gastrointestinal permeability.

    Conclusions:

    • Children with atopic eczema exhibit enhanced gastrointestinal permeability.
    • This increased permeability may represent a primary gut abnormality.
    • Alternatively, it could result from intestinal mucosal damage due to food antigen hypersensitivity.