Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles
Anatoly A Peshkov1,2, Diana Gapanenok1, Aleksandra Puzyk1
1Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russian Federation.
Abstract:
A chemoselective strategy toward a variety of fused heterocyclic scaffolds relying on a three-component condensation of heterocyclic ketene aminals (HKAs) or corresponding thioaminals with aryl glyoxals and cyclic 1,3-dicarbonyl compounds has been developed and explored. Depending on the applied combination of substrates, the strategy can be tuned to provide straightforward access to imidazo[1,2-a]quinoline, pyrrolo[1,2-a]imidazole, and pyrrolo[2,1-b]thiazole frameworks.
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