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The Predictive Role of Hematological Parameters in Hypertension

Xiangzhu Meng1, Hong Sun2, Xiaowen Tu1

  • 1Department of Cardiology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi, China.

Angiology
|July 17, 2023
PubMed

Insights

New hematological parameters can help predict hypertension (HT) and its complications. These inexpensive markers, including neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII), offer valuable insights for early screening and patient management.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Inflammation Research

Background:

  • Hypertension (HT) is a major global health issue, linked to target-organ damage and cardiovascular mortality.
  • Inflammation is increasingly recognized as a key factor in HT development and progression.
  • Conventional inflammatory markers for HT are often costly and less accessible than routine blood tests.

Purpose of the Study:

  • To review the diagnostic and prognostic value of novel hematological parameters in hypertension.
  • To assess the utility of parameters like NLR, MHR, RDW, PLR, MPV, PDW, and SII as biomarkers for HT.

Main Methods:

  • Comprehensive literature search of PubMed and Embase databases up to September 18, 2022.
  • Analysis of studies investigating the association between hematological parameters and hypertension.
  • Focus on parameters reflecting inflammation and platelet activation.

Main Results:

  • Several hematological parameters, including neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL cholesterol ratio (MHR), red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and systemic immune-inflammation index (SII), show potential as HT biomarkers.
  • These parameters are easily obtainable from routine blood tests and are cost-effective.
  • Evidence suggests their utility in predicting HT diagnosis and prognosis.

Conclusions:

  • Hematological parameters offer a promising, accessible approach for early hypertension screening and risk stratification.
  • These biomarkers can aid in optimizing the management strategies for patients with hypertension.
  • Further research into these parameters can enhance cardiovascular disease prevention and treatment.

Keywords:
hematological parametershypertensionneutrophil to lymphocyte ratioplatelet activationred cell distribution widthsystemic immune-inflammation index

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