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Updated: Jul 23, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Atherosclerosis and Epigenetic Modifications in Chronic Kidney Disease

Nejc Piko1, Sebastjan Bevc2,3, Radovan Hojs2,3

  • 1Department of Dialysis, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.

Nephron
|July 17, 2023
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in chronic kidney disease (CKD) and its link to cardiovascular disease. Understanding miRNA dysregulation is key to managing CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) affects 10% of the global population, with cardiovascular disease (CVD) being the primary cause of death.
  • CKD patients face a disproportionately high burden of CVD, linked to atherosclerosis and vascular stiffness.
  • Standard markers like estimated glomerular filtration rate and proteinuria indicate kidney function and cardiovascular risk.

Purpose of the Study:

  • To summarize the current understanding of microRNA (miRNA) involvement in the pathophysiology of CKD.
  • To highlight the role of miRNA dysregulation in CKD-associated cardiovascular complications.

Main Methods:

  • Review of existing scientific literature on miRNAs in CKD and cardiovascular disease.
  • Analysis of studies investigating the regulatory functions of miRNAs in disease pathways.

Main Results:

  • MicroRNAs are small non-coding RNAs that regulate gene expression by impacting mRNA translation and degradation.
  • Dysregulation of miRNAs is implicated in the development and progression of both CKD and atherosclerosis.
  • miRNAs are integral to the complex interplay between kidney disease and cardiovascular risk.

Conclusions:

  • MicroRNA dysregulation is a significant factor in the pathophysiology of CKD.
  • Further research into miRNAs may offer novel therapeutic targets for reducing cardiovascular risk in CKD patients.

Keywords:
AtherosclerosisChronic kidney diseaseMicroRNA

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