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Updated: Jul 23, 2025

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MMP-2 and its implications on cardiac function and structure: Interplay with inflammation in hypertension

Thaís Ribeiro Vitorino1, Alejandro Ferraz do Prado2, Stefany Bruno de Assis Cau3

  • 1Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, UNICAMP, Brazil.

Biochemical Pharmacology
|July 17, 2023
PubMed

Insights

Hypertension contributes to heart failure through inflammation. Targeting matrix metalloproteinase-2 (MMP-2) may reduce cardiac damage and inflammation in hypertensive heart disease.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Immunology

Background:

  • Hypertension is a primary risk factor for heart failure development.
  • Inflammatory cells and cytokines play a crucial role in cardiac remodeling and dysfunction.
  • Cardiac remodeling involves the activation of extracellular matrix metalloproteinases (MMPs).

Purpose of the Study:

  • To review the role of matrix metalloproteinase-2 (MMP-2) in hypertension-induced cardiac remodeling and injury.
  • To explore signaling pathways involving cytokines and inflammatory cells in MMP-2 regulation.
  • To investigate the interplay between MMP-2 and inflammation in maintaining cardiac function.

Main Methods:

  • Review of preclinical and clinical studies.
  • Analysis of signaling pathways regulating MMP-2 transcription, secretion, and activation.
  • Exploration of the interaction between MMP-2 and inflammatory mediators.

Main Results:

  • Increased MMP-2 levels contribute to cardiac remodeling and injury in hypertension.
  • Cytokines and inflammatory cells significantly influence MMP-2 activity.
  • MMP-2 and inflammation exhibit coordinated action impacting the cardiac cycle.

Conclusions:

  • MMP-2 is a key mediator in hypertension-related cardiac damage.
  • Targeting MMP-2 presents a potential therapeutic strategy for hypertensive heart disease.
  • Therapeutic interventions focused on MMP-2 may reduce inflammatory biomarkers and cardiac injury.

Keywords:
Cardiac remodelingHypertensionInflammationMMP-2

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