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Related Experiment Video

Updated: Jul 23, 2025

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An inflammation-responsive double-layer microneedle patch for recurrent atopic dermatitis therapy.

Liwan Song1, Junjie Chi2, Zhenglin Li3

  • 1Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325025, China; School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, 325025, China.

International Journal of Pharmaceutics
|July 17, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces an inflammation-responsive microneedle patch delivering Vitamin D3 (VD3) for atopic dermatitis (AD) therapy. The patch effectively treats AD symptoms and prevents recurrence by releasing VD3 and hyaluronic acid in response to inflammation.

Keywords:
Atopic dermatitisDouble-layerInflammation-responsiveMicroneedleRecurrence prevention

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Nanotechnology

Background:

  • Atopic dermatitis (AD) poses significant challenges for effective treatment and prevention of recurrence.
  • Current therapeutic strategies often struggle to provide sustained relief and address disease relapse.
  • There is a critical need for innovative approaches to manage AD effectively.

Purpose of the Study:

  • To develop an inflammation-responsive double-layer microneedle (IDMN) patch for in situ delivery of Vitamin D3 (VD3) for recurrent atopic dermatitis (AD) therapy.
  • To investigate the therapeutic efficacy and recurrence-prevention capabilities of the IDMN patch.
  • To explore the synergistic effects of VD3 and hyaluronic acid (HA) in treating AD.

Main Methods:

  • Fabrication of an IDMN patch with an inner gelatin methacryloyl (GelMA) layer loaded with VD3 and an outer hyaluronic acid (HA) layer.
  • Utilizing the inflammation-responsive degradation of GelMA by matrix metalloproteinase (MMP) for controlled VD3 release.
  • Evaluating the IDMN patch's performance in AD-bearing mouse models, assessing symptom alleviation and recurrence inhibition.

Main Results:

  • The IDMN patch demonstrated efficient therapeutic effects, including suppression of erythema, scaling, and lichenification, alongside reduced epidermal thickness and inflammation.
  • Synergistic action between released VD3 and dissolved HA contributed to the observed "curing" performances.
  • Residual microneedle tips retained in the skin after initial treatment showed a "warning" ability to inhibit AD recurrence.

Conclusions:

  • The developed IDMN patch offers a promising therapeutic strategy for atopic dermatitis (AD) by providing localized, inflammation-responsive delivery of VD3.
  • The patch's dual action of symptom alleviation and recurrence prevention highlights its potential for managing relapsing skin diseases.
  • IDMN patches represent an innovative candidate for clinical application in treating AD and other recurrent inflammatory conditions.