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Angiogenesis induction as a key step in cardiac tissue Regeneration: From angiogenic agents to biomaterials
Haniyeh Malektaj1, Shirin Nour2, Rana Imani3
1Department of Materials and Production, Aalborg University, Fibigerstraede 16, Aalborg 9220, Denmark.
Insights
Inducing angiogenesis, the formation of new blood vessels, is crucial for repairing heart tissue after myocardial infarction. This review classifies methods for promoting angiogenesis to improve cardiac function and regeneration.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Regenerative Medicine
Background:
- Cardiovascular diseases are the primary global cause of mortality.
- Myocardial infarction leads to cardiac tissue damage, scar formation, and dysfunction.
- Angiogenesis is essential for nutrient and oxygen supply in cardiac tissue engineering.
Purpose of the Study:
- To review and classify diverse strategies for inducing angiogenesis in cardiac tissue repair.
- To present a framework for understanding pro-angiogenic signaling pathway induction.
- To highlight the potential of these approaches in cardiac regeneration.
Main Methods:
- Classification of angiogenesis induction methods.
- Review of engineered biomaterials for pro-angiogenic signaling.
- Analysis of drug and angiogenic factor applications.
- Examination of combinatorial therapeutic strategies.
Main Results:
- A comprehensive classification of angiogenesis induction techniques is presented.
- Engineered biomaterials, drugs, and factors are key to pro-angiogenic signaling.
- Combinatorial approaches offer a promising platform for cardiac regeneration.
Conclusions:
- Angiogenesis induction is vital for effective cardiac tissue repair and regeneration.
- These methods hold significant potential for improving patient outcomes.
- Development involves interdisciplinary collaboration between academia and industry.
Abstract:
Cardiovascular diseases are the leading cause of death worldwide. After myocardial infarction, the vascular supply of the heart is damaged or blocked, leading to the formation of scar tissue, followed by several cardiac dysfunctions or even death. In this regard, induction of angiogenesis is considered as a vital process for supplying nutrients and oxygen to the cells in cardiac tissue engineering. The current review aims to summarize different approaches of angiogenesis induction for effective cardiac tissue repair. Accordingly, a comprehensive classification of induction of pro-angiogenic signaling pathways through using engineered biomaterials, drugs, angiogenic factors, as well as combinatorial approaches is introduced as a potential platform for cardiac regeneration application. The angiogenic induction for cardiac repair can enhance patient treatment outcomes and generate economic prospects for the biomedical industry. The development and commercialization of angiogenesis methods often involves collaboration between academic institutions, research organizations, and biomedical companies.
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