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[Effect of serotonin on uteroplacentofetal circulatory system in pregnant rabbit]
The effects of serotonin (5-hydroxytryptamine) on the uteroplacentofetal circulatory system were studied in pregnant rabbits. Serotonin infusion (50 micrograms/kg) induced transient, but significant fetal bradycardia (deceleration), without any significant changes in maternal blood pressure, heart rates, pO2, pCO2 and uterine activities. Pretreatment with methysergide, a serotonin antagonist, with a dose of 2.5 mg/kg blocked the inhibitory effect of serotonin on fetal heart rate. However, methysergide itself produced the uterine contraction associated with mild fetal bradycardia. Direct injection of serotonin (1,000 micrograms/kg) into fetuses did not produce any changes in fetal heart rates. These data indicated that serotonin would influence the uteroplacental vasculature, which in turn induced fetal bradycardia.
The effects of serotonin (5-hydroxytryptamine) on the uteroplacentofetal circulatory system were studied in pregnant rabbits. Serotonin infusion (50 micrograms/kg) induced transient, but significant fetal bradycardia (deceleration), without any significant changes in maternal blood pressure, heart rates, pO2, pCO2 and uterine activities. Pretreatment with methysergide, a serotonin antagonist, with a dose of 2.5 mg/kg blocked the inhibitory effect of serotonin on fetal heart rate. However, methysergide itself produced the uterine contraction associated with mild fetal bradycardia. Direct injection of serotonin (1,000 micrograms/kg) into fetuses did not produce any changes in fetal heart rates. These data indicated that serotonin would influence the uteroplacental vasculature, which in turn induced fetal bradycardia.