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Autosomal dominant polycystic kidney disease in Colombia

Jessica T Camargo1, Camilo A González2, Lina Herrera3

  • 1Fundación Universitaria Sanitas, Bogotá, D.C, Colombia.

BMC Nephrology
|July 17, 2023
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) prevalence in Colombia was 9.81 per 100,000 people. Higher rates were found in Valle del Cauca and Cali, indicating potential areas for genetic studies.

Area of Science:

  • Nephrology
  • Genetics
  • Epidemiology

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of chronic kidney disease (CKD) requiring dialysis.
  • Understanding ADPKD geographical distribution is crucial for early diagnosis, disease management, and genetic counseling.

Purpose of the Study:

  • To determine the prevalence, geographic distribution, and ethnic demographics of ADPKD patients undergoing dialysis or kidney transplant in Colombia.
  • To identify geographical clusters of ADPKD within Colombia between 2015 and 2019.

Main Methods:

  • A cross-sectional study utilizing data from Colombia's National Registry of Chronic Kidney Disease (NRCKD) from July 2015 to June 2019.
  • Inclusion of Colombian individuals with CKD, with or without renal replacement therapy (RRT), specifically due to ADPKD.
  • Estimation of crude and adjusted prevalence rates stratified by state and city.

Main Results:

  • A total of 3,339 ADPKD patients were analyzed; period prevalence was 9.81 per 100,000 population.
  • The highest adjusted prevalence rates were observed in Valle del Cauca (6.55/100,000) and Cali (9.38/100,000).
  • 46.07% of patients initiated scheduled dialysis, with a mean age of 52.58 years; 52.78% were women.

Conclusions:

  • ADPKD prevalence in Colombia appears lower than in Europe and the US.
  • Specific states with higher prevalence, such as Valle del Cauca, warrant further investigation for genetic prevalence studies.
Abstract

Keywords:
Chronic kidney failureDialysisKidney transplantPolycystic kidney diseaseRenal replacement therapy

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