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The Association Between Depression and Invasive and In-situ Cervical Tumors: A Large Population Based Cohort Study
Ravit Bassal1, Varda Shalev2, Vered H Eisenberg3
1Israel Center for Disease Control, Ministry of Health, Sheba Medical Center, Tel Hashomer, Israel, Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Women with depression face a significantly higher risk of cervical tumors (CTs). This risk escalates with the presence of multiple co-morbidities, underscoring the need for increased gynecological surveillance in this population.
Area of Science:
- Oncology
- Psychiatry
- Epidemiology
Background:
- Depression is a known risk factor for various cancers.
- Previous studies suggest a link between depression and cervical tumors (CTs), but lacked temporal clarity.
Purpose of the Study:
- To investigate the association between depression and CTs.
- To evaluate the impact of co-morbidities on this association within a large cohort.
Main Methods:
- Retrospective cohort study of 357,450 women.
- Depression diagnosis based on International Classification of Diseases (ICD) codes.
- Zero-inflated negative binomial regression used to calculate relative risk (RR) for CTs.
Main Results:
- Women with depression had a significantly higher incidence of CTs (10.0% vs. 1.2%).
- Adjusted RR for CTs in depressed women was 9.2 (95% CI 8.7-9.9).
- The association between depression and CTs intensified with an increased burden of co-morbidities.
Conclusions:
- Women diagnosed with depression exhibit an elevated risk for developing CTs.
- This risk is particularly pronounced in women with multiple co-existing health conditions.
- Enhanced gynecological surveillance is recommended for women with depression, especially those with co-morbidities.
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