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Updated: Jul 23, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease

Koki Mise1,2, Jianyin Long1, Daniel L Galvan3

  • 1Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Research Square
|July 18, 2023
PubMed
Summary

Targeting NDUFS4, a mitochondrial complex I subunit, improves kidney function in diabetic mice by enhancing mitochondrial structure and reducing albuminuria. This suggests NDUFS4 is a key regulator for slowing diabetic kidney disease progression.

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