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Role of orexin in pathogenesis of neurodegenerative parkinsonisms

Piotr Alster1, Natalia Madetko-Alster2, Dagmara Otto-Ślusarczyk3

  • 1Department of Neurology, Medical University of Warsaw, Warsaw, Poland.

Neurologia I Neurochirurgia Polska
|July 18, 2023
PubMed
Abstract

Insights

This study explores the role of orexin, a neuropeptide linked to wakefulness, in parkinsonian syndromes. Understanding orexin

Area of Science:

  • Neuroendocrinology
  • Neurodegenerative Diseases

Background:

  • Parkinsonism pathogenesis remains unclear, with potential roles for endocrine abnormalities.
  • Orexin, a hypothalamic neuropeptide, influences arousal, wakefulness, and appetite.

Purpose of the Study:

  • To discuss the role of orexin and its abnormalities in the pathogenesis and progression of parkinsonian syndromes.
  • To investigate whether orexin metabolism changes are a cause or consequence of neurodegeneration.

Main Methods:

  • Literature review and analysis of existing research on orexin and parkinsonism.

Main Results:

  • Orexin's functions in wakefulness and appetite suggest a potential link to neurodegenerative processes.
  • Abnormalities in orexin metabolism may contribute to the development or progression of parkinsonian syndromes.

Conclusions:

  • Orexin plays a role in parkinsonian syndromes, highlighting its potential as a therapeutic target.
  • Further research with larger patient cohorts is necessary to fully elucidate orexin's impact.
Keywords:
PSPParkinson’s Diseasehypothalamusorexinparkinsonism

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