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Recent Developments in the Design of New Water-Soluble Boron Dipyrromethenes and Their Applications: An Updated
Chandra Sekhara Mahanta1, Velayutham Ravichandiran1, Sharada Prasanna Swain1
1Department of Medicinal Chemistry and Centre for Marine Therapeutics, National Institute of Pharmaceutical Education and Research- Kolkata, 168, Chunilal Bhawan, Maniktala Main Road, Kolkata 700054, India.
Abstract:
Boron-dipyrromethene (BODIPY) and its derivatives play an important role in the area of organic fluorophore chemistry. Recently, the water-soluble boron-dipyrromethene dyes have increasingly received interest. The structural modification of the BODIPY core by incorporating different neutral and ionic hydrophilic groups makes it water-soluble. The important hydrophilic groups, such as quaternary ammonium, sulfonate, oligoethylene glycol, dicarboxylic acid, and sugar moieties significantly increase the solubility of these dyes in water while preserving their photophysical properties. As a result, these fluorescent dyes are utilized in aqueous systems for applications such as chemosensors, cell imaging, anticancer, biolabeling, biomedicine, metal ion detection, and photodynamic treatment. This review covers the most current developments in the design and synthesis of water-soluble BODIPY derivatives and their wide applications since 2014.
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