Related Experiment Video
Updated: Jul 23, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
TECLISTAMAB-ASSOCIATED SCLEROUVEITIS WITH HYPOPYON
Tianyu Liu1, Turner Schwartz1, Apoorv P Chebolu1
1Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Purpose:
To report a case of presumed teclistamab-associated sclerouveitis with hypopyon.
Methods:
Case report.
Results:
A 62-year-old woman with relapsed refractory multiple myeloma presented with right eye pain and decreased vision 1 week after starting teclistamab and was found to have sclerouveitis with hypopyon. She received intravitreal vancomycin and ceftazidime because of the concern for infectious endophthalmitis, but cultures were negative. Systemic workup for infectious and inflammatory etiologies was unremarkable. Her signs and symptoms improved with topical steroids and a 1-week pause in teclistamab. This case constituted a Naranjo Adverse Drug Reaction Probability Scale score of 5, representing a "probable" association.
Conclusion:
Teclistamab, a novel bispecific antibody recently approved for the treatment of relapsed or refractory multiple myeloma, may be associated with sclerouveitis with hypopyon.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Immunotherapy
Nephrotic Syndrome II : Assessment and Medical Management

