Obesity Paradox in Lung Diseases: What Explains It?
Surui Yao1, Lei Zeng1, Fengyuan Wang2
1School of Public Health, Chengdu Medical College, Chengdu, China.
Obesity Facts
|July 18, 2023
Summary
Obesity paradox describes better outcomes in some lung diseases for obese patients. This review explores immune response, fibrosis, and lung function mechanisms potentially explaining this phenomenon.
Area of Science:
- Pulmonology
- Metabolic Diseases
- Immunology
Background:
- Obesity is a global health issue affecting multiple organ systems.
- It significantly impacts lung function and disease pathophysiology.
- Paradoxically, obesity is linked to better prognoses in certain lung diseases like pneumonia and COPD.
Purpose of the Study:
- To review and summarize proposed mechanisms behind the obesity paradox in lung diseases.
- To discuss factors altered by obesity, including immune response, fibrosis, lung function, microbiota, and body reserves.
- To examine confounding factors and conflicting literature regarding the obesity paradox.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of immunological, physiological, and metabolic alterations associated with obesity.
- Discussion of epidemiological findings and potential confounding variables.
Main Results:
- Obesity alters immune responses, pulmonary fibrosis, lung function, and body composition.
- These alterations may contribute to the observed better prognosis in some lung diseases.
- Conflicting data suggests confounding factors may also play a role.
Conclusions:
- Understanding the obesity paradox in lung diseases requires investigating obesity-related physiological changes.
- Further research is needed to elucidate the complex interplay between obesity and lung disease outcomes.
- This review provides insights for future clinical and basic research.
Keywords:
Acute lung injuryAcute respiratory distress syndromeChronic obstructive pulmonary diseaseLung cancerObesity paradoxPneumoniaMore Related Videos
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