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Association between Mild Cognitive Impairment and Gut Microbiota in Elderly Korean Patients

Eun-Ju Kim1, Jae-Seong Kim1, Seong-Eun Park1

  • 1Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Journal of Microbiology and Biotechnology
|July 18, 2023
PubMed

Insights

This study identified specific gut bacteria differences in Korean elderly with mild cognitive impairment (MCI). Findings highlight potential microbial markers for MCI in this population.

Area of Science:

  • Microbiology
  • Gerontology
  • Neurology

Background:

  • Gut microbiota composition varies globally and is implicated in diseases like Alzheimer's.
  • Previous research has not detailed the gut microbiome characteristics of Korean mild cognitive impairment (MCI) patients.

Purpose of the Study:

  • To investigate the association between gut microbiota and MCI in the elderly Korean population.
  • To identify potential gut microbial markers specific to Korean MCI patients.

Main Methods:

  • 16S rRNA gene amplicon sequencing was performed on fecal samples from 40 Korean MCI patients and 40 controls.
  • Comparative analysis of gut microbial community profiles and relative abundance of specific genera was conducted.

Main Results:

  • While overall microbial profiles showed no significant differences, the relative abundance of genera such as Bacteroides, Prevotella, and Akkermansia differed significantly between MCI and control groups.
  • A negative correlation was observed between Prevotella and Bacteroides relative abundance (r = 0.733).

Conclusions:

  • Gut microbiota composition in Korean elderly MCI patients exhibits distinct patterns compared to controls.
  • Specific bacterial genera may serve as potential biomarkers for identifying MCI in the Korean elderly population.
Keywords:
KoreanMild cognitive impairmentgut microbiotagut-brain axisrace

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