Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

449
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
449
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

310
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
310
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K
Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

Antiasthma Drugs: Muscarinic Receptor Antagonists

342
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
342

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rilzabrutinib for patients with moderate-to-severe asthma with uncontrolled symptoms: a double-blind, placebo-controlled, phase 2 study.

The Lancet. Respiratory medicine·2026
Same author

Violence-Related Distress, Nasal Epithelial Gene Expression, and T17-High Asthma in Youth.

Pediatric pulmonology·2026
Same author

Intermediate monocytes in blood correlate with subclinical vascular changes in lupus nephritis.

Lupus science & medicine·2025
Same author

Connectome-Based Predictive Modeling of Trait Mindfulness.

Human brain mapping·2025
Same author

Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents.

Allergy, asthma & immunology research·2024
Same author

Leveraging the Consolidated Framework for Implementation Research to Develop the American College of Rheumatology's Toolkit for Implementation of Rheumatoid Arthritis Outcome Measures in Clinical Practice: A Qualitative Study.

Arthritis care & research·2024

Related Experiment Video

Updated: Jul 23, 2025

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

43.1K

Brain-Airway Interactions in Asthma.

William Busse1, Christie Bartels2, Melissa Rosenkranz3

  • 1Department of Medicine, Division of Allergy Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. wwb@medicine.wisc.edu.

Advances in Experimental Medicine and Biology
|July 18, 2023
PubMed
Summary
This summary is machine-generated.

Asthma impacts brain health, increasing risks for mood disorders and potentially dementia. Research is exploring how airway inflammation affects brain function and neurodegeneration, aiming to find preventative treatments.

Keywords:
Alzheimers diseaseAnxietyAsthma-brain interactionsCo-morbidityDepressionHeterogeneityNeurodegenerationPsychological disordersSystemic inflammation

More Related Videos

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

57.0K
Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.4K

Related Experiment Videos

Last Updated: Jul 23, 2025

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

43.1K
Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

57.0K
Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.4K

Area of Science:

  • Neuroscience
  • Immunology
  • Pulmonology

Background:

  • Asthma is linked to increased anxiety and depression, suggesting bidirectional brain-asthma interactions.
  • Early life stressors are risk factors for asthma, while asthma itself increases the risk for mood and anxiety disorders.

Purpose of the Study:

  • To explore the communication pathways between asthma and brain health.
  • To investigate the link between asthma, systemic inflammation, and neurodegenerative diseases like dementia.

Main Methods:

  • Review of epidemiological and neuroimaging studies.
  • Analysis of how allergen challenges affect brain responses to emotional stimuli.
  • Examination of brain white matter changes in asthma patients.

Main Results:

  • Asthma provokes changes in brain activation related to emotional processing.
  • Systemic inflammation in asthma affects the brain, similar to neuroinflammation in Alzheimer's disease.
  • Asthma patients show white matter brain changes resembling neurodegenerative conditions.

Conclusions:

  • Bidirectional links between asthma and brain health are confirmed.
  • Further research is needed to define asthma-brain interactions in neurodegeneration.
  • Investigating asthma-focused treatments may prevent adverse brain health effects.