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Racial disparities in conditional survival of patients with bladder cancer: a population-based study
Wei Liu1,2,3, Jie Xiong1,2, Honghao Wang1,2
1Department of Urology, Aerospace Center Hospital, Beijing, China.
BMC Urology
|July 18, 2023
Summary
African Americans with bladder cancer show initially poorer survival but achieve comparable outcomes to white and Asian/Pacific Islander patients after several years. Race becomes less predictive of prognosis as survival time increases.
Area of Science:
- Oncology
- Epidemiology
- Biostatistics
Background:
- Traditional cancer outcome predictions are static and do not account for race's evolving impact.
- Assessing dynamic survival is crucial for understanding racial disparities in bladder cancer prognosis.
Purpose of the Study:
- To reveal dynamic survival patterns in bladder cancer patients.
- To explore the evolving effect of race on bladder cancer patient prognosis.
Main Methods:
- Utilized data from 110,371 bladder cancer patients (White, African American, Asian/Pacific Islander) from the SEER registry.
- Estimated conditional cancer-specific survival (CSS) rates using Kaplan-Meier algorithm.
- Evaluated the evolving effect of race on survival via multivariable Cox regression with conditional survival (CS) estimates.
Main Results:
- African American patients showed improving CSS over time, reaching levels comparable to White and API patients after 4 years.
- The trend of improving survival over time was observed across all racial groups and patient subsets.
- The risk of death for African Americans decreased with increased survival time, becoming statistically similar to White patients after 4 years.
Conclusions:
- Despite worse initial survival, African Americans with bladder cancer can achieve comparable long-term survival to other racial groups.
- Race's predictive power for poorer prognosis diminishes as bladder cancer patient survival time increases.
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