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Pumped and pumpless microphysiological systems to study (nano)therapeutics.

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Microphysiological systems (MPS) offer advanced in vitro models for drug and nanomaterial evaluation. Pumpless MPS, using gravity-driven flow, show promise for assessing nanomaterial toxicity and biodistribution.

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Area of Science:

  • Toxicology
  • Nanomedicine
  • Biotechnology

Background:

  • Microphysiological systems (MPS) are advanced microfluidic cell culture devices.
  • They better mimic in vivo human tissue microenvironments compared to traditional cell culture methods.
  • MPS are valuable tools for drug discovery and toxicity testing, including nanomaterials.

Purpose of the Study:

  • To review recent advances in pumped and pumpless MPS design and application.
  • To highlight the potential of pumpless MPS in evaluating nanomaterials.
  • To discuss the role of MPS in assessing nanomaterial uptake, biodistribution, elimination, and toxicity.

Main Methods:

  • Discussion of recent advances in microphysiological system design.
  • Focus on pumpless MPS utilizing gravity for medium recirculation.
  • Comparison of pumped and pumpless MPS for nanomaterial evaluation.

Main Results:

  • Pumpless MPS offer advantages in mimicking physiological conditions with near-physiological fluid volumes.
  • Recent advances enhance the utility of MPS for evaluating nanomaterial interactions with tissues.
  • Both pumped and pumpless MPS are crucial for comprehensive nanomaterial assessment.

Conclusions:

  • Pumpless MPS represent a significant advancement in microphysiological systems.
  • These systems are increasingly important for the toxicological assessment of nanomaterials.
  • MPS are poised to play a key role in the future of nanomedicine and drug development.