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Related Experiment Video

Updated: Jul 23, 2025

Murine Fecal Isolation and Microbiota Transplantation
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Causal associations between gut microbiota and sepsis: A two-sample Mendelian randomization study.

Jingya You1, Xiaogang Bi1, Kouxing Zhang1

  • 1Department of General Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

European Journal of Clinical Investigation
|July 19, 2023
PubMed
Summary

Targeting gut microbiota may help prevent sepsis. This study identified specific intestinal flora, like Order Victivallales, causally linked to lower sepsis risk and mortality, offering potential biomarkers and therapeutic targets.

Keywords:
Mendelian randomizationgut microbiotasepsis

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Area of Science:

  • Microbiome research
  • Genetics
  • Infectious disease epidemiology

Background:

  • The gut microbiota's role in sepsis prevention and treatment is a promising area.
  • However, the specific causal links between gut bacteria and sepsis remain largely unknown.

Purpose of the Study:

  • To investigate the causal relationship between specific intestinal microflora and the risk and prognosis of sepsis.
  • To identify potential gut microbial biomarkers for early sepsis diagnosis and therapeutic targets.

Main Methods:

  • A two-sample Mendelian randomization (MR) study utilized genome-wide association study (GWAS) summary statistics for gut microbiota (n=18,340) and sepsis (n=486,484).
  • Standard MR methods (inverse-variance weighted, weighted median, MR-Egger) and sensitivity analyses were employed to assess causality.
  • Bonferroni correction was used to determine the significance of identified relationships.

Main Results:

  • Nine intestinal microflora were found to have a causal association with sepsis risk.
  • Eleven intestinal microflora were causally linked to 28-day mortality in sepsis patients.
  • Order Victivallales demonstrated a significant protective effect, reducing sepsis risk (OR=0.86) and 28-day mortality (OR=0.68).
  • No significant pleiotropy was detected, supporting the validity of the findings.

Conclusions:

  • This MR study identified specific gut bacteria causally associated with sepsis risk and prognosis.
  • Findings suggest that Order Victivallales may serve as a biomarker for reduced sepsis risk and mortality.
  • These gut microbes represent potential targets for novel sepsis diagnostic and therapeutic strategies.