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Injectable ice slurry for reducing pericardial adipose tissue.
Jeffrey Shuhaiber1, Sara Moradi Tuchayi1, Felicitas J Bijari2
1Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lasers in Surgery and Medicine
|July 19, 2023
Summary
Injectable ice slurry safely and effectively reduced pericardial adipose tissue (PAT) volume in a preclinical model. This novel cryolipolysis approach shows potential for treating cardiovascular diseases by targeting excess PAT.
Area of Science:
- Cardiology
- Medical Devices
- Adipose Tissue Research
Background:
- Excess pericardial adipose tissue (PAT) is linked to increased cardiovascular disease risk.
- Current PAT reduction methods (diet, exercise, medication, surgery) suffer from poor long-term patient compliance.
- A novel injectable ice slurry technology offers selective subcutaneous adipose tissue reduction.
Purpose of the Study:
- To evaluate the feasibility and safety of using an injectable ice slurry for selective reduction of pericardial adipose tissue (PAT) volume.
- To assess the efficacy of slurry injection in a large animal model.
Main Methods:
- Pericardial adipose tissue (PAT) in Yucatan swine was injected with either ice slurry or a control solution.
- Chest computed tomography (CT) was used for PAT volume quantification at baseline and 2 months post-injection.
- Histological analysis was performed on harvested PAT specimens.
Main Results:
- Slurry treatment was well-tolerated, inducing selective cryolipolysis in PAT.
- CT imaging revealed a significant reduction in PAT volume (median -29.66%) in the slurry-treated group compared to controls (-1.50%) at 8 weeks (p < 0.05).
Conclusions:
- Injectable slurry is a feasible and safe method for selectively reducing PAT volume in a large animal model.
- This cryolipolysis technique effectively reduces PAT, suggesting potential as a novel therapeutic strategy for cardiovascular diseases.
