Related Experiment Video
Updated: Jul 23, 2025
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
10.2K
New treatment options in elderly patients with Diffuse Large B-cell Lymphoma
Annalisa Arcari1, Federica Cavallo2, Benedetta Puccini3
1Hematology and Bone Marrow Transplant Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Frontiers in Oncology
|July 19, 2023
Summary
Older patients with Diffuse Large B-cell Lymphoma (DLBCL) require tailored treatments. New immunotherapies show promise for relapsed/refractory cases and potentially frail patients, offering a chemo-free alternative.
Area of Science:
- Oncology
- Geriatric Medicine
- Hematology
Background:
- Diffuse Large B-cell Lymphoma (DLBCL) predominantly affects older adults (>65 years).
- The aging population necessitates adapted treatment strategies for DLBCL.
- Geriatric assessment is crucial for determining appropriate treatment intensity in elderly DLBCL patients.
Purpose of the Study:
- To review novel therapeutic approaches for elderly patients with Diffuse Large B-cell Lymphoma (DLBCL).
- To evaluate the efficacy and safety of emerging immunotherapies in relapsed/refractory DLBCL, especially in non-transplant-eligible patients.
- To explore the potential of chemo-free immunotherapy as a curative option for frail elderly DLBCL patients.
Main Methods:
- Review of current literature on DLBCL treatment in older adults.
- Analysis of data on new therapies including polatuzumab vedotin, tafasitamab, and bispecific antibodies.
- Assessment of clinical trial results for novel agents in first-line and relapsed/refractory settings.
Main Results:
- New immunotherapies demonstrate promising results in relapsed/refractory DLBCL, particularly for non-transplant-eligible patients.
- Several novel agents are being investigated in first-line treatment, alone or in combination, to improve upon standard chemotherapy.
- Preliminary data suggest potential efficacy and acceptable safety profiles for these new treatments.
Conclusions:
- Treatment intensity for elderly DLBCL patients should be guided by geriatric assessment.
- Novel immunotherapies offer new hope for relapsed/refractory DLBCL patients, including those ineligible for transplant.
- A future chemo-free immunotherapy approach may provide a curative treatment option for even frail elderly DLBCL patients, pending further clinical validation.
More Related Videos
11:15Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
8.0K
06:15Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
27.4K
Related Concept Videos
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
01:27Tumor Immunotherapy
560
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
560
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:22Bone Marrow Sampling and Transplants
360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
360
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K