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Related Experiment Videos

Theophylline toxicity in children.

M D Baker

    The Journal of Pediatrics
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Theophylline toxicity in children often presents with vomiting and CNS excitation. Careful dosing and monitoring of serum theophylline levels can prevent most toxicity cases.

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    Area of Science:

    • Pediatric Pharmacology
    • Clinical Toxicology

    Background:

    • Theophylline is a medication used for respiratory conditions.
    • Theophylline toxicity can lead to serious adverse events in children.

    Purpose of the Study:

    • To review cases of theophylline toxicity in children.
    • To identify common manifestations and causes of toxicity.
    • To suggest preventive measures.

    Main Methods:

    • Retrospective review of 65 pediatric cases of theophylline toxicity.
    • Analysis of clinical manifestations and serum theophylline concentrations.

    Main Results:

    • Common symptoms include vomiting, tachycardia, and central nervous system excitation.
    • Seizures occurred at serum levels below 70 µg/ml in some cases.

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  • Dosing errors were the primary cause of toxicity.

    • Conclusions:

    • Careful medication history and diligent serum theophylline monitoring are crucial for prevention.
    • Early recognition of symptoms can guide management.
    • Preventable dosing errors underscore the need for improved prescribing and monitoring practices.