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Mirikizumab for the treatment of moderate to severe ulcerative colitis

Jurij Hanzel1,2, Christopher Ma2,3, Vipul Jairath2,4,5

  • 1Department of Gastroenterology, Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia.

Immunotherapy
|July 19, 2023
PubMed

Despite a growing number of available therapeutic options for ulcerative colitis (UC), up to 50% of patients do not respond to initial treatment or lose response over time, highlighting the need for novel therapies. The IL-23 pathway has emerged as an important therapeutic target for UC. Mirikizumab is a humanized IgG4 monoclonal antibody against the p19 subunit of IL-23, dosed intravenously during induction and subcutaneously during maintenance. It is effective for the induction and maintenance of remission in moderately to severely active UC, including patients with prior failure of biological or tofacitinib therapy. Like other IL-23 antagonists, mirikizumab has a favorable safety profile. It is the first agent of its class to receive regulatory approval for moderately to severely active UC in Europe.

Keywords:
IL-23biological therapyclinical trialsinflammatory bowel diseasetherapeutic monoclonal antibodies

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