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Advances in Targeting Drug Biological Carriers for Enhancing Tumor Therapy Efficacy

Donglin Xia1, Jia Li1, Lingzi Feng1

  • 1School of Public Health, Nantong University, Nantong, Jiangsu, 226019, P.R. China.

Macromolecular Bioscience
|July 19, 2023
PubMed

Insights

Biological carriers enhance chemotherapy drug delivery for cancer treatment. These biomimetic nanoparticles improve drug efficacy and reduce toxicity, showing promise for clinical translation.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Chemotherapy is a cornerstone of cancer treatment, but faces challenges with drug delivery efficiency and off-target toxicity.
  • Biological carriers offer a solution by camouflaging synthetic nanoparticles for targeted drug delivery, improving biocompatibility and biodegradability.

Purpose of the Study:

  • To review recent advancements in biological vectors for targeted chemotherapy drug delivery.
  • To highlight stimuli-responsive release systems and their potential clinical applications.
  • To discuss the future trends and clinical translation possibilities of biological drug carriers.

Main Methods:

  • Literature review of recent developments in biological carriers for drug delivery.
  • Focus on biomimetic nanoparticles derived from cells (e.g., red blood cells, platelets, tumor cells, immune cells) and their membranes.
  • Analysis of microenvironmental stimuli-responsive release mechanisms.

Main Results:

  • Biological carriers, including cell membranes, demonstrate excellent biocompatibility and biodegradability for drug delivery.
  • These carriers significantly improve drug delivery efficiency and therapeutic efficacy in vivo.
  • Stimuli-responsive release systems enhance targeted drug delivery to tumor sites.

Conclusions:

  • Biological carriers represent a promising strategy to overcome chemotherapy limitations.
  • Further research and development are crucial for clinical translation and exploitation of these targeted drug delivery systems.
Keywords:
biological vectorlong-loop recyclingtargeted deliverytumor therapy

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